Joints & Bones

Joints & Bones Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• C 55 Vitamin K2 (MK-7, menaquinone-7) x Bone health and vascular calcification/calcium metabolism
  Mechanism and some RCT signals exist, but bone findings for MK-7 alone are not robustly reproduced and vascular evidence is centered on CAC/valve i... · View verdict →
• C 50 Gelatin x Joints, skin, and hair
  Standalone gelatin clinical evidence is at a surrogate-marker level, while positive joint, skin, and hair RCTs mostly involve specific hydrolyzed c... · View verdict →
• C 48 Undenatured type II collagen (UC-II) x Joint pain, function, and flexibility
  Clinical symptom and function markers improve in several small RCTs and a limited meta-analysis, but key UC-II evidence is short-term, heavily indu... · View verdict →
• C 48 Curcumin (turmeric, curcumin/turmeric) x Anti-inflammatory and joint health
  Short-term relief of pain and functional impairment in knee osteoarthritis is supported at a B level by multiple RCTs and meta-analyses, but genera... · View verdict →
• C 45 Calcium (supplement) x Bone health, maintenance of bone mineral density, and fracture prevention
  Bone mineral density rises slightly, but it is a surrogate marker; for fracture prevention, independent large RCTs and recent meta-analyses do not... · View verdict →
• D 35 Chondroitin (chondroitin, mainly chondroitin sulfate) x Claims for joint and cartilage health, improvement of osteoarthritis pain and function, and maintenance of joint space
  The mechanism that the ingredient is a cartilage component, absorption rate, and surrogate markers such as joint space width do not directly transl... · View verdict →
• C score not listed Green-lipped mussel oil (New Zealand green-lipped mussel) x joint pain relief
  The evidence is conflicting or limited. · View verdict →
• C score not listed Boswellia serrata (frankincense) x joint inflammation and pain relief
  The evidence is conflicting or limited. · View verdict →
• C score not listed Collagen (hydrolyzed/UC-II) x joint and bone health
  The evidence is conflicting or limited · View verdict →
• D score not listed Glucosamine x joint (knee) pain and function improvement
  Human evidence is insufficient or was not confirmed in key trials. · View verdict →
• D score not listed MSM (methylsulfonylmethane) x joint pain and function improvement
  Human evidence is insufficient or was not confirmed in key trials. · View verdict →