CATEGORY HUB
Liver
Liver verdicts ranked by evidence score. 101 verdicts in this category.
47 foods and supplements claimed to help liver health, ranked by evidence
Drugs and procedures removed — only what you swallow, ordered by how strong the evidence is.
Liver Evidence Ranking
Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.
| A | 91 | Inactivated hepatitis A vaccine (prescription vaccine) | Prevention of symptomatic hepatitis A in nonimmune children and high-risk adults |
| A | 90 | Sorafenib (oral prescription multikinase inhibitor targeting VEGFR and RAF; Nexavar) | Prolonged overall survival as initial systemic therapy for unresectable advanced hepatocellular carcinoma |
| A | 86 | Elbasvir/grazoprevir (fixed-dose direct-acting antiviral combination, Zepatier, prescription medicine) | Virologic cure at 12 weeks after treatment for chronic hepatitis C genotypes 1 and 4 |
| A | 86 | Hepatitis B vaccine (recombinant or plasma-derived HBsAg vaccine) | Prevention of clinical and subclinical hepatitis B virus infection |
| A | 84 | Propranolol (nonselective beta blocker; prescription drug) | Prevention of a first variceal bleed in cirrhosis with large esophageal varices |
| B | 79 | Glecaprevir/pibrentasvir (Mavyret, prescription direct-acting antiviral combination) | Virologic cure at SVR12 after eight weeks of treatment for chronic hepatitis C |
| B | 79 | Sofosbuvir/velpatasvir (Epclusa; prescription direct-acting antiviral combination) | Sustained virologic response 12 weeks after treatment across all chronic hepatitis C genotypes |
| B | 79 | Intravenous N-acetylcysteine or acetylcysteine (prescription thiol antidote injection; Cysten) | Prevent or lessen hepatotoxicity and liver failure after acute acetaminophen overdose |
| B | 79 | Sofosbuvir/velpatasvir/voxilaprevir (three-drug fixed-dose DAA combination, Vosevi, prescription medicine) | SVR12 virologic cure on retreatment of chronic hepatitis C after failure of an NS5A-containing DAA regimen |
| B | 78 | Ursodeoxycholic acid (UDCA) | Improvement of cholestasis and disease progression in primary biliary cholangitis |
| B | 78 | Human serum albumin 20% is a concentrated plasma-protein biologic manufactured from human plasma and administered intravenously by prescription. | The claim is that adding albumin to antibiotics in cirrhosis with spontaneous bacterial peritonitis reduces renal impairment and in-hospital mortality. |
| B | 78 | Ledipasvir/sofosbuvir (prescription NS5A and NS5B direct-acting antiviral combination; Harvoni) | Sustained virologic response 12 weeks after a 12-week course in treatment-naive chronic hepatitis C genotype 1 |
| B | 76 | Rifaximin (Normix; prescription gut-targeted antibiotic) | Reduced recurrence of hepatic encephalopathy and related hospitalization in patients with cirrhosis |
| B | 76 | Lactulose (nonabsorbable disaccharide, prescription medicine) | Prevention of recurrent overt hepatic encephalopathy in patients with cirrhosis |
| B | 76 | Carvedilol (nonselective beta and alpha-1 blocker; prescription medicine, Dilatrend; off-label for portal hypertension) | Prevent a first decompensating event in compensated cirrhosis with clinically significant portal hypertension |
| B | 76 | Early transjugular intrahepatic portosystemic shunt (early TIPS; covered-stent shunt procedure) | Reduction in rebleeding and one-year mortality after high-risk acute variceal bleeding in cirrhosis |
| B | 76 | Laparoscopic parenchyma-sparing liver resection for resectable colorectal liver metastases | Reduction of clinically relevant surgical complications within 30 days |
| B | 75 | Nivolumab plus ipilimumab (intravenous immune-checkpoint inhibitor combination, prescription anticancer therapy) | Longer overall survival than lenvatinib or sorafenib as first-line therapy for unresectable or metastatic hepatocellular carcinoma |
| B | 73 | Tenofovir disoproxil fumarate (TDF, Viread, prescription) | Long-term viral suppression and reduction of fibrosis and disease progression in chronic hepatitis B |
| B | 72 | Atezolizumab plus bevacizumab (prescription intravenous PD-L1 inhibitor plus anti-VEGF monoclonal antibody; Tecentriq plus Avastin) | Longer overall and progression-free survival than sorafenib in unresectable hepatocellular carcinoma without prior systemic therapy |
| B | 72 | Durvalumab (PD-L1-blocking monoclonal antibody; prescription anticancer infusion, Imfinzi) | Prolonged overall survival when added to gemcitabine and cisplatin as first-line treatment for unresectable or metastatic biliary tract cancer |
| B | 72 | Regorafenib (multitarget tyrosine-kinase inhibitor, Stivarga, oral prescription anticancer drug) | Prolonged overall survival in hepatocellular carcinoma that progressed after sorafenib |
| B | 69 | Lenvatinib (oral prescription multikinase inhibitor targeting VEGFR and FGFR; Lenvima) | Overall survival noninferior to sorafenib in previously untreated unresectable hepatocellular carcinoma |
| B | 68 | Lamivudine (nucleoside antiviral, Zeffix, prescription medicine) | Reduced clinical progression of liver disease in chronic hepatitis B with advanced fibrosis or cirrhosis |
| B | 68 | Human albumin 20% (plasma-protein biologic, prescription intravenous infusion) | Reduced mortality and hospitalization with long-term weekly administration in decompensated cirrhosis with ascites |
| B | 63 | Ursodeoxycholic acid (UDCA, prescription bile-acid gallstone dissolution medicine) | Dissolution of small noncalcified cholesterol gallstones in a functioning gallbladder |
| C | 59 | Vitamin E (alpha-tocopherol) | Improvement in liver histology in patients with MASH or NASH without diabetes or cirrhosis |
| C | 59 | Pioglitazone (Actos, a thiazolidinedione) | MASH/NASH resolution and improvement in liver fibrosis and histology |
| C | 58 | Entecavir (nucleoside-analogue antiviral, Baraclude, prescription) | Prevention of cirrhosis, liver cancer, and liver-related death in chronic hepatitis B |
| C | 58 | Resmetirom (a prescription thyroid hormone receptor-beta agonist, marketed as Rezdiffra) | MASH resolution and at least one-stage fibrosis improvement in noncirrhotic MASH with F2 to F3 fibrosis |
| C | 58 | Tenofovir alafenamide (TAF, prescription nucleotide reverse-transcriptase inhibitor antiviral) | Viral suppression noninferior to TDF with better renal and bone safety in chronic hepatitis B |
| C | 58 | Peginterferon alfa-2a (prescription injectable pegylated-interferon antiviral biologic; Pegasys) | Sustained viral suppression and HBeAg seroconversion after a finite 48-week course in selected patients with chronic hepatitis B |
| C | 58 | Semaglutide 2.4 mg (prescription injectable GLP-1 receptor agonist; Wegovy) | Resolution of steatohepatitis and improvement of liver fibrosis by at least one stage in F2-F3 MASH |
| C | 56 | NAC (N-acetylcysteine) | liver, respiratory health, and antioxidant effects |
| C | 56 | Caffeinated coffee at two to four or more cups daily, with cup volume unreported | Prevention of symptomatic gallstone disease and cholecystectomy |
| C | 56 | Sugar-sweetened beverages | Higher incidence of liver cancer |
| C | 56 | Six-monthly alpha-fetoprotein testing plus liver ultrasonography surveillance in adults at high risk from hepatitis B or chronic hepatitis | Reduced hepatocellular-carcinoma mortality |
| C | 55 | Hovenia dulcis fruit extract (HDE; hovenic acid) | Liver health and hangover |
| C | 55 | L-ornithine L-aspartate (LOLA) | Improvement of cirrhotic hepatic encephalopathy and hyperammonemia |
| C | 55 | Bezafibrate (an oral prescription fibrate and pan-PPAR agonist; off-label for PBC) | Improved complete biochemical response and pruritus in primary biliary cholangitis with inadequate UDCA response |
| C | 54 | Branched-chain amino acids (BCAAs: leucine, isoleucine, and valine; medical nutrition and supplements) | Improvement of consciousness and neuropsychiatric symptoms in cirrhosis-related hepatic encephalopathy |
| C | 54 | Seladelpar (selective PPAR-delta agonist, Livdelzi, prescription drug) | Improved ALP-bilirubin biochemical response and pruritus in primary biliary cholangitis with inadequate UDCA response |
| C | 54 | Empagliflozin 10 mg, a prescription SGLT2 inhibitor | Reduction in MRI-measured liver fat in MASLD with type 2 diabetes |
| C | 53 | Black seed oil, a Nigella sativa seed-oil herbal supplement containing thymoquinone | Improvement of ALT, AST, and ultrasound steatosis in MASLD or nonalcoholic fatty liver disease |
| C | 52 | Artemisia annua extract powder | Liver protection and liver-function improvement |
| C | 52 | Metadoxine (500-mg prescription medicine for alcohol-associated liver disease) | Accelerated recovery of alcoholic fatty liver and normalization of liver enzymes |
| C | 52 | Ciprofloxacin (prescription fluoroquinolone antibiotic) | Primary prevention of spontaneous bacterial peritonitis (SBP) and death in cirrhosis with low-protein ascites |
| C | 52 | Terlipressin (vasopressin V1 agonist; intravenous prescription injection) | Verified reversal of renal dysfunction in cirrhosis-associated hepatorenal syndrome with acute kidney injury |
| C | 52 | Resistant starch (RS2, digestion-resistant starch, food and supplement) | Reduction of intrahepatic triglyceride and liver fat in patients with MASLD/NAFLD |
| C | 50 | Choline: choline bitartrate, phosphatidylcholine/lecithin, citicoline/CDP-choline, and alpha-GPC/choline alfoscerate | Liver health/fatty liver and cognition/memory |
| C | 50 | Ecklonia stolonifera extract | Liver health and liver-enzyme improvement |
| C | 50 | Elafibranor 80 mg oral tablet | Improved the alkaline-phosphatase and bilirubin composite biochemical response in primary biliary cholangitis with inadequate UDCA response |
| C | 50 | 100% Korean pear juice, 220 mL | Reduced hangover symptoms after alcohol |
| C | 49 | L-ornithine | Hangover and liver-fatigue improvement |
| C | 48 | Lactobacillus-fermented kelp extract | Liver function and liver-marker improvement |
| C | 48 | Lemon balm-dandelion complex LD100 | Liver health and improvement in liver enzymes |
| C | 48 | Live multistrain probiotics containing Lactobacillus and Bifidobacterium species, including synbiotics (dietary supplements) | Improved liver fat, ALT, AST, and liver stiffness in adults with MASLD or NAFLD |
| C | 48 | Naltrexone (mu-opioid receptor antagonist; prescription medicine) | Relief of refractory pruritus in cholestatic liver disease |
| C | 46 | Milk thistle (silymarin) | liver health and fatigue improvement |
| C | 46 | Prednisolone (systemic glucocorticoid, Solondo, prescription medicine) | Reduction of 28-day, 90-day, and one-year mortality in severe alcohol-related hepatitis |
| C | 45 | Korean black raspberry extract powder (individually recognized ingredient No. 2010-62) | Improvement of alcoholic liver-injury markers |
| C | 44 | Sesamin (sesame lignan) | Lipids and blood pressure, and fatty liver and liver enzymes |
| C | 44 | Curcumin (turmeric curcuminoids, a turmeric-derived polyphenol supplement) | Improvement of liver fat and ALT and AST in MASLD or NAFLD |
| C | 43 | Tauroursodeoxycholic acid (TUDCA) | Improvement in fatty liver and liver enzymes |
| C | 43 | Biphenyl dimethyl dicarboxylate, DDB (prescription hepatotonic) | Improvement of liver-disease progression and prognosis through ALT normalization |
| C | 42 | Licorice glycyrrhizin | Improvement in hepatitis and liver enzymes |
| C | 41 | Picrorhiza kurroa (kutki) extract | Improvement in liver function and liver enzymes |
| C | 41 | Honeyberry extract powder | Protection from liver injury associated with metabolic abnormalities |
| C | 41 | Betaine, trimethylglycine, or TMG for liver outcomes | Improvement of fatty liver, liver fat, and liver enzymes |
| C | 41 | Oral glutathione | Liver detoxification, toxin elimination, and improvement in liver enzymes |
| C | 41 | SAMe, or S-adenosyl-L-methionine and ademetionine, a methyl donor sold as a supplement | Reduced risk of death or liver transplantation in alcoholic cirrhosis |
| C | 40 | Calcium D-glucarate | Enhanced liver detoxification and toxin elimination |
| C | 40 | Probiotics-fermented garlic extract (individually approved functional ingredient No. 2016-16) | Improved liver enzymes and support for liver health |
| C | 40 | Green tea extract or EGCG (catechin supplement) | Improved liver enzymes including ALT and AST in MASLD or NAFLD |
| D | 38 | Maralixibat (Livmarli, oral IBAT inhibitor solution) | Relief of cholestatic pruritus in children with Alagille syndrome |
| D | 33 | Coffee, a conventional food beverage containing caffeine and chlorogenic-acid polyphenols | Prevention of cirrhosis and hepatocellular carcinoma through long-term consumption |
| D | 32 | Dandelion (Taraxacum) | Liver, diuretic effect, and digestion |
| D | 32 | Omega-3 fatty acids (fish-oil-derived EPA and DHA supplements) | Improvement of liver fat, liver enzymes, and histology in MASLD or NAFLD |
| D | 30 | Metformin (a prescription biguanide) | Prevention of hepatocellular carcinoma in people with type 2 diabetes and chronic liver disease |
| D | 30 | A 16:8 schedule restricting food intake to 08:00-16:00 | Additional liver-fat reduction beyond equal daily calorie restriction |
| D | 28 | Resveratrol (a stilbene polyphenol supplement) | Improvement of liver fat, alanine aminotransferase, aspartate aminotransferase, and histologic fatty liver in metabolic dysfunction-associated or nonalcoholic fatty liver disease |
| D | 28 | A palm-olein diet supplying 20% of total energy | Whether liver fat increases versus soybean oil or cocoa butter |
| D | 25 | Chanca piedra (Phyllanthus niruri) | Liver protection and detoxification |
| D | 25 | Dendropanax morbiferus extract (a traditional Araliaceae plant extract and supplemental food) | Relief of hangover and improvement of alcohol-related liver injury and liver enzymes |
| D | 25 | Spanish black radish extract (Raphanus sativus var. niger, a cruciferous-plant supplement) | Improved acetaminophen metabolism and toxin elimination by activating hepatic detoxification enzymes |
| D | 25 | Fermented or aged black garlic (food or supplement containing S-allylcysteine) | Improved ALT and AST and protection of liver function in healthy adults |
| D | 25 | High-dose ursodeoxycholic acid, or UDCA, 28 to 30 mg/kg/day as oral tablets | Reduced risk of liver transplantation, cirrhosis, and death in primary sclerosing cholangitis |
| D | 25 | Obeticholic acid (Ocaliva oral tablets) | Prevention of clinical progression, including death, transplantation, and hepatic decompensation, in primary biliary cholangitis with inadequate response to UDCA |
| D | 23 | Acer tegmentosum extract (traditional maple-family ingredient and supplement) | Relief of hangover and improvement of alcohol-related liver injury, fatty liver, and liver enzymes |
| F | 10 | Ursodeoxycholic acid (UDCA) | Improvement of liver histology and fibrosis in MASH/NASH |
| F | 8 | Activated charcoal capsules (porous carbon adsorbent supplement) | Reduced alcohol absorption, blood alcohol, and hangover when taken before or after drinking |
| ? | score not listed | Dihydromyricetin (DHM) | Hangover prevention and relief |
| ? | score not listed | Artemisia capillaris extract | Liver detoxification and hangover improvement |
| ? | score not listed | Burdock root (Arctium lappa) | Liver detoxification and blood purification |
| ? | score not listed | Caper bush root (Capparis spinosa; an ingredient in LiverCare/Liv.52) | Hepatocyte protection and liver detoxification |
| ? | score not listed | Freeze-dried bovine liver glandular for oral use | Liver detoxification and liver-function support |
| ? | score not listed | Castor-oil liver pack (Ricinus communis oil, a ricinoleic-acid-rich topical wellness product) | Liver detoxification and improvement of liver enzymes and fatty liver through right-upper-abdominal application |
| ? | score not listed | Apple cider vinegar (ACV, an acetic-acid fermented food and supplement) | Improvement of liver fat, alanine aminotransferase, and fibrosis in metabolic dysfunction-associated or nonalcoholic fatty liver disease |
| ? | score not listed | Wheatgrass, the young leaves of Triticum aestivum used as a green-food powder or juice supplement | Liver detoxification and improvement of liver enzymes and liver fat in MASLD |
| ? | score not listed | Whole minari (Oenanthe javanica) | Relief of hangover symptoms |
| ? | score not listed | Coffee enema | Liver detoxification and toxin elimination |