FOOD & SUPPLEMENT BUNDLE
Foods and supplements claimed to help liver health
47 of them, ranked by strength of evidence. None reach grade A or B.
At a glance
47 foods and supplements marketed for liver health, each graded one by one against clinical trial evidence. Grade spread: C 28 · D 10 · F 1. None reach grade A or B.
The grade measures how strong the evidence is, not how good something is for you. Grade A means independent research groups replicated a reduction in real clinical events in humans; grade F means well-designed trials established there is no effect. See Methodology.
Claimed to help liver health — strongest evidence first
Within a grade, higher scores come first; verdicts without a score sit at the bottom. Follow a name to see its trials, evidence, and limits.
| C | 59 | Vitamin E (alpha-tocopherol) | Improvement in liver histology in patients with MASH or NASH without diabetes or cirrhosis |
| C | 56 | NAC (N-acetylcysteine) | liver, respiratory health, and antioxidant effects |
| C | 56 | Caffeinated coffee at two to four or more cups daily, with cup volume unreported | Prevention of symptomatic gallstone disease and cholecystectomy |
| C | 55 | Hovenia dulcis fruit extract (HDE; hovenic acid) | Liver health and hangover |
| C | 53 | Black seed oil, a Nigella sativa seed-oil herbal supplement containing thymoquinone | Improvement of ALT, AST, and ultrasound steatosis in MASLD or nonalcoholic fatty liver disease |
| C | 52 | Artemisia annua extract powder | Liver protection and liver-function improvement |
| C | 52 | Resistant starch (RS2, digestion-resistant starch, food and supplement) | Reduction of intrahepatic triglyceride and liver fat in patients with MASLD/NAFLD |
| C | 50 | Choline: choline bitartrate, phosphatidylcholine/lecithin, citicoline/CDP-choline, and alpha-GPC/choline alfoscerate | Liver health/fatty liver and cognition/memory |
| C | 50 | Ecklonia stolonifera extract | Liver health and liver-enzyme improvement |
| C | 50 | 100% Korean pear juice, 220 mL | Reduced hangover symptoms after alcohol |
| C | 49 | L-ornithine | Hangover and liver-fatigue improvement |
| C | 48 | Lactobacillus-fermented kelp extract | Liver function and liver-marker improvement |
| C | 48 | Lemon balm-dandelion complex LD100 | Liver health and improvement in liver enzymes |
| C | 48 | Live multistrain probiotics containing Lactobacillus and Bifidobacterium species, including synbiotics (dietary supplements) | Improved liver fat, ALT, AST, and liver stiffness in adults with MASLD or NAFLD |
| C | 46 | Milk thistle (silymarin) | liver health and fatigue improvement |
| C | 45 | Korean black raspberry extract powder (individually recognized ingredient No. 2010-62) | Improvement of alcoholic liver-injury markers |
| C | 44 | Sesamin (sesame lignan) | Lipids and blood pressure, and fatty liver and liver enzymes |
| C | 44 | Curcumin (turmeric curcuminoids, a turmeric-derived polyphenol supplement) | Improvement of liver fat and ALT and AST in MASLD or NAFLD |
| C | 43 | Tauroursodeoxycholic acid (TUDCA) | Improvement in fatty liver and liver enzymes |
| C | 42 | Licorice glycyrrhizin | Improvement in hepatitis and liver enzymes |
| C | 41 | Picrorhiza kurroa (kutki) extract | Improvement in liver function and liver enzymes |
| C | 41 | Honeyberry extract powder | Protection from liver injury associated with metabolic abnormalities |
| C | 41 | Betaine, trimethylglycine, or TMG for liver outcomes | Improvement of fatty liver, liver fat, and liver enzymes |
| C | 41 | Oral glutathione | Liver detoxification, toxin elimination, and improvement in liver enzymes |
| C | 41 | SAMe, or S-adenosyl-L-methionine and ademetionine, a methyl donor sold as a supplement | Reduced risk of death or liver transplantation in alcoholic cirrhosis |
| C | 40 | Calcium D-glucarate | Enhanced liver detoxification and toxin elimination |
| C | 40 | Probiotics-fermented garlic extract (individually approved functional ingredient No. 2016-16) | Improved liver enzymes and support for liver health |
| C | 40 | Green tea extract or EGCG (catechin supplement) | Improved liver enzymes including ALT and AST in MASLD or NAFLD |
| D | 33 | Coffee, a conventional food beverage containing caffeine and chlorogenic-acid polyphenols | Prevention of cirrhosis and hepatocellular carcinoma through long-term consumption |
| D | 32 | Dandelion (Taraxacum) | Liver, diuretic effect, and digestion |
| D | 32 | Omega-3 fatty acids (fish-oil-derived EPA and DHA supplements) | Improvement of liver fat, liver enzymes, and histology in MASLD or NAFLD |
| D | 30 | A 16:8 schedule restricting food intake to 08:00-16:00 | Additional liver-fat reduction beyond equal daily calorie restriction |
| D | 28 | Resveratrol (a stilbene polyphenol supplement) | Improvement of liver fat, alanine aminotransferase, aspartate aminotransferase, and histologic fatty liver in metabolic dysfunction-associated or nonalcoholic fatty liver disease |
| D | 25 | Chanca piedra (Phyllanthus niruri) | Liver protection and detoxification |
| D | 25 | Dendropanax morbiferus extract (a traditional Araliaceae plant extract and supplemental food) | Relief of hangover and improvement of alcohol-related liver injury and liver enzymes |
| D | 25 | Spanish black radish extract (Raphanus sativus var. niger, a cruciferous-plant supplement) | Improved acetaminophen metabolism and toxin elimination by activating hepatic detoxification enzymes |
| D | 25 | Fermented or aged black garlic (food or supplement containing S-allylcysteine) | Improved ALT and AST and protection of liver function in healthy adults |
| D | 23 | Acer tegmentosum extract (traditional maple-family ingredient and supplement) | Relief of hangover and improvement of alcohol-related liver injury, fatty liver, and liver enzymes |
| F | 8 | Activated charcoal capsules (porous carbon adsorbent supplement) | Reduced alcohol absorption, blood alcohol, and hangover when taken before or after drinking |
| ? | score not listed | Dihydromyricetin (DHM) | Hangover prevention and relief |
| ? | score not listed | Artemisia capillaris extract | Liver detoxification and hangover improvement |
| ? | score not listed | Burdock root (Arctium lappa) | Liver detoxification and blood purification |
| ? | score not listed | Caper bush root (Capparis spinosa; an ingredient in LiverCare/Liv.52) | Hepatocyte protection and liver detoxification |
| ? | score not listed | Freeze-dried bovine liver glandular for oral use | Liver detoxification and liver-function support |
| ? | score not listed | Apple cider vinegar (ACV, an acetic-acid fermented food and supplement) | Improvement of liver fat, alanine aminotransferase, and fibrosis in metabolic dysfunction-associated or nonalcoholic fatty liver disease |
| ? | score not listed | Wheatgrass, the young leaves of Triticum aestivum used as a green-food powder or juice supplement | Liver detoxification and improvement of liver enzymes and liver fat in MASLD |
| ? | score not listed | Whole minari (Oenanthe javanica) | Relief of hangover symptoms |
Not swallowed — applied, inhaled, held in the mouth, worn, or performed on the body (2)
Same claims, but these are not taken by mouth: rubbed on the skin, breathed in, chewed or rinsed and spat out, worn on the body, or performed as a procedure such as acupuncture or cupping. A different route into the body, so they are listed separately.
| ? | score not listed | Castor-oil liver pack (Ricinus communis oil, a ricinoleic-acid-rich topical wellness product) | Liver detoxification and improvement of liver enzymes and fatty liver through right-upper-abdominal application |
| ? | score not listed | Coffee enema | Liver detoxification and toxin elimination |
Claimed to harm liver health (2)
Here a higher grade means the harm is better established — the opposite direction from the table above. A low grade means the claim of harm rests on weak evidence.
| C | 56 | Sugar-sweetened beverages | Higher incidence of liver cancer |
| D | 28 | A palm-olein diet supplying 20% of total energy | Whether liver fat increases versus soybean oil or cocoa butter |
What does have evidence for liver health
Not foods or supplements: drugs and procedures graded A or B. Chamgap recommends nothing. It only shows where the evidence is strong. Any treatment decision belongs with your doctor.
| A | 91 | Inactivated hepatitis A vaccine (prescription vaccine) | Prevention of symptomatic hepatitis A in nonimmune children and high-risk adults |
| A | 90 | Sorafenib (oral prescription multikinase inhibitor targeting VEGFR and RAF; Nexavar) | Prolonged overall survival as initial systemic therapy for unresectable advanced hepatocellular carcinoma |
| A | 86 | Elbasvir/grazoprevir (fixed-dose direct-acting antiviral combination, Zepatier, prescription medicine) | Virologic cure at 12 weeks after treatment for chronic hepatitis C genotypes 1 and 4 |
| A | 86 | Hepatitis B vaccine (recombinant or plasma-derived HBsAg vaccine) | Prevention of clinical and subclinical hepatitis B virus infection |
| A | 84 | Propranolol (nonselective beta blocker; prescription drug) | Prevention of a first variceal bleed in cirrhosis with large esophageal varices |
| B | 79 | Glecaprevir/pibrentasvir (Mavyret, prescription direct-acting antiviral combination) | Virologic cure at SVR12 after eight weeks of treatment for chronic hepatitis C |
| B | 79 | Sofosbuvir/velpatasvir (Epclusa; prescription direct-acting antiviral combination) | Sustained virologic response 12 weeks after treatment across all chronic hepatitis C genotypes |
| B | 79 | Intravenous N-acetylcysteine or acetylcysteine (prescription thiol antidote injection; Cysten) | Prevent or lessen hepatotoxicity and liver failure after acute acetaminophen overdose |
| B | 79 | Sofosbuvir/velpatasvir/voxilaprevir (three-drug fixed-dose DAA combination, Vosevi, prescription medicine) | SVR12 virologic cure on retreatment of chronic hepatitis C after failure of an NS5A-containing DAA regimen |
| B | 78 | Ursodeoxycholic acid (UDCA) | Improvement of cholestasis and disease progression in primary biliary cholangitis |
| B | 78 | Human serum albumin 20% is a concentrated plasma-protein biologic manufactured from human plasma and administered intravenously by prescription. | The claim is that adding albumin to antibiotics in cirrhosis with spontaneous bacterial peritonitis reduces renal impairment and in-hospital mortality. |
| B | 78 | Ledipasvir/sofosbuvir (prescription NS5A and NS5B direct-acting antiviral combination; Harvoni) | Sustained virologic response 12 weeks after a 12-week course in treatment-naive chronic hepatitis C genotype 1 |
How to read this list
A grade of C or D does not mean "do not take it." It means the evidence is not yet strong enough to promise the effect. Equally, A or B does not mean it works for everyone.
Chamgap sells nothing and takes no advertising. See all Liver verdicts.