Antioxidant & Aging

Antioxidant & Aging Evidence Ranking

Within this category, verdicts with higher evidence scores appear first. Verdicts without a score stay lower in the same list.

• C 56 Grape seed extract (proanthocyanidins/OPC) x Antioxidant, vascular, and edema effects
  Blood pressure shows a small positive signal, but the core antioxidant, vascular, and edema claims rely on surrogate markers and small/industry-fun... · View verdict →
• C 52 Pycnogenol (French maritime pine bark extract) x Antioxidant, vascular, and skin effects
  Human RCTs and meta-analyses exist, but antioxidant, vascular, and skin claims are all centered on short-term surrogate markers, with limits in ind... · View verdict →
• C 48 Resveratrol x anti-aging and cardiovascular
  Anti-aging lacks human clinical endpoints for lifespan or delayed aging, and the SIRT1 meta-analysis was negative overall. Cardiovascular evidence... · View verdict →
• C 48 Alpha-lipoic acid (ALA, alpha-lipoic acid, thioctic acid) x antioxidant, blood glucose, and nerves
  There are signals for short-term improvement in diabetic nerve symptoms, but long-term neuroprotection and blood-glucose/antioxidant health effects... · View verdict →
• F 10 Vitamin E (high-dose alpha-tocopherol; mainly d-alpha or dl-alpha-tocopherol/acetate, including products of 400 IU or higher) x Antioxidant and cardiovascular health/cardiovascular disease prevention
  High-dose alpha-tocopherol has a plausible antioxidant mechanism, but large RCTs and meta-analyses repeatedly show no benefit on primary cardiovasc... · View verdict →
• D score not listed NMN (nicotinamide mononucleotide) x anti-aging and NAD+ increase
  Human evidence is insufficient or was not confirmed in key trials · View verdict →