Verdict No. 277 · Search date 2026-07-11 · Methodology v0.6
Fadogia agrestis,
does it really help with Increased testosterone and male vitality?
30-Second Summary
?
Evidence Grade ? · Safety caution
Human efficacy trials are absent, so testosterone and vitality effects cannot be judged
What the
research showsNo human efficacy trial evaluating testosterone or male vitality was identified. The known positive signals come from hormone and sexual-behavior outcomes in male rats, so the human efficacy grade is ?.
research showsNo human efficacy trial evaluating testosterone or male vitality was identified. The known positive signals come from hormone and sexual-behavior outcomes in male rats, so the human efficacy grade is ?.
What the
ads claimAdvertisements combine claims of testosterone boosting, libido, strength, and vitality, but no human study has directly tested them.
ads claimAdvertisements combine claims of testosterone boosting, libido, strength, and vitality, but no human study has directly tested them.
Useful facts when choosing a product
- Positive efficacy signals come from male-rat studies, not human studies.
- The aqueous extract used in animal research has not been shown to match the source material or standardization of marketed capsules.
- No effective human dose or long-term human safety profile has been established.
Gap Measurement · Verdict 277 · ?
What the research actually shows
Yakubu 2005 reported increased serum testosterone and sexual behavior after five days of an aqueous stem extract in male rats. Yakubu 2008 and 2009 reported abnormal signals in testicular-function markers and liver and kidney cell-membrane integrity after 28-day repeat dosing. No human efficacy trial was identified.
Why this is classified as ?
Because no human efficacy literature exists, the grade is ? and the score is null regardless of the direction of preclinical evidence.
Counterpoint. A testosterone signal exists in rodents, but it cannot be converted into a human effect estimate.
Rejudgment record. New verdict — No human testosterone or vitality efficacy trial; only animal evidence is available
Cross-check — Codex and Claude
This verdict was drafted by Codex through literature review and source-existence checks, cross-checked through blind grading and adversarial audit, and settled by reapplying the methodology boundary rules. Cases with split grades were resolved through rejudgment.
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Yakubu MT et al. 2005 | Male-rat animal study | Unknown | Serum testosterone and sexual behavior | Five-day dosing increased testosterone and selected sexual-behavior measures. | Preclinical | |
| Yakubu MT et al. 2008 | Twenty-eight-day repeat-dose male-rat study | 4 | Unknown | Biochemical markers of testicular function | Abnormal changes related to testicular function were reported at all tested doses. | Safety, preclinical |
| Yakubu MT et al. 2009 | Twenty-eight-day male-rat toxicity study | 4 | Unknown | Liver and kidney enzymes and lipid peroxidation | Possible compromise of hepatocyte and nephron cell-membrane integrity was reported. | Safety, preclinical |
Receipt — 3 References
All 3 cited sources were verified for existence at the original page (as of 2026-07-11).
Yakubu MT, Akanji MA, Oladiji AT. Aphrodisiac potentials of the aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male albino rats. Asian J Androl. 2005;7(4):399-404. DOI: 10.1111/j.1745-7262.2005.00052.x.
checkedYakubu MT, Akanji MA, Oladiji AT. Effects of oral administration of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem on some testicular function indices of male rats. J Ethnopharmacol. 2008;115(2):288-292. PMID: 18023305. DOI: 10.1016/j.jep.2007.10.004.
checkedYakubu MT, Oladiji AT, Akanji MA. Mode of cellular toxicity of aqueous extract of Fadogia agrestis (Schweinf. Ex Hiern) stem in male rat liver and kidney. Hum Exp Toxicol. 2009;28(8):469-478. PMID: 19755438. DOI: 10.1177/0960327109106973.
checkedDraft and rewrite: Codex (AI) · Verification: Codex blind grading and adversarial audit · Final adjudication: Claude
Reviewed and approved: Chamgap Editorial Team · Approval date: 2026-07-11 · Corrections: none
Reviewed and approved: Chamgap Editorial Team · Approval date: 2026-07-11 · Corrections: none
Cite this verdict
[Chamgap] Fadogia agrestis x increased testosterone and male vitality — Evidence Grade ?. 3 cited sources checked. Source: https://health-receipt.pages.dev/en/verdicts/mens/fadogia-agrestis-testosterone-vitality/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
What this document does and does not do
Chamgap is an information source. It reports what research has and has not confirmed; it does not tell readers what to take or buy. That decision belongs to readers and, when needed, medical or legal professionals. This verdict reflects literature available up to the search date and may change as new research appears. Nothing here is medical advice.