Single blastocyst-stage embryo transfer,
does it really help with Cumulative live birth after up to three transfers versus cleavage-stage transfer?
research showsThe grade is B with 72 points. Cumulative live birth after up to three transfers was 372/497 (74.8%) versus 328/495 (66.3%), absolute difference 8.6 points (95% CI 2.9-14.2), RR 1.13 (95% CI 1.04-1.22).
ads claimVerdict 1900 is F with 10 points and studies PGT-A in the same population and endpoint, but the intervention is embryo-biopsy selection. Verdict 2351 is B with 76 points and asks embryo number and multiple birth. Verdict 2384 is D with 34 points and asks time-lapse selection. This verdict asks developmental stage: blastocyst versus cleavage stage. The four questions differ. The 11 Chinese academic centers enrolled only good-prognosis women aged 20-40 years with at least three transferable cleavage-stage embryos. The result cannot be transferred unchanged to populations with different laboratory performance, patient selection, or transfer rules, including South Korean practice, or to poor-prognosis women.
Useful facts when choosing a product
- Women were followed through up to three single-embryo transfers.
- Fewer frozen embryos remained after blastocyst culture.
- Chinese 11-center results may vary with Korean laboratory performance, transfer limits, and case mix.
What the research actually shows
Eleven Chinese academic centers randomized 992 good-prognosis IVF women, 497 versus 495, with all included in ITT. Limitation name: noninferiority design. List item: noninferiority design. Avoidability: possible - cumulative live-birth superiority could have been the primary hypothesis. Participants and embryology laboratories were not blinded, but live birth is a record-confirmed hard event, so this was not an unblinded subjective endpoint and was not counted as a separate limitation. The only declared threshold was the -10-point noninferiority margin; sample-size assumptions were not treated as thresholds. No separate clinically important superiority threshold was declared, so axis 5 is null. Funding was Chinese public funding with no verified industry sponsorship.
Why this is classified as B (72)
A publicly funded multicenter RCT with a hard live-birth benefit supports B, tempered by a single open-label noninferiority design.
Counterpoint. Higher cumulative live birth must be balanced against fewer frozen embryos and perinatal safety signals.
Rejudgment record. Cross-check applied — Cross-checked Nature Communications report, protocol, and registry for live-birth definition, -10-point margin, ITT denominators, frozen embryos, multiplicity, perinatal outcomes, and public funding
| Endpoint | H | Hard endpoint - actual events such as death |
| Replication | R1 | Single confirmatory trial |
| Independence | I2 | Decisive evidence is publicly or non-profit funded |
| Effect size | E+ | Meets the clinically important threshold |
The scoring table and the verdict agree (B).
Sub-claim grades by effect
This ingredient is marketed for several effects. A single overall grade blends strong and weak claims together, so each effect is graded separately here. The overall grade reflects the strongest disconfirming or core claim.
| Effect (sub-claim) | Grade | Basis |
|---|---|---|
| Higher cumulative live birth | B | The absolute difference was 8.6 points. |
| Perinatal safety | ? | Preterm-related signals appeared, but individual harms were underpowered. |
Cross-check — Codex and Claude
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Study 1 | Open-label multicenter randomized noninferiority trial | 495 | Chinese national, provincial, and university public grants; no verified industry sponsorship | Cumulative live birth after up to three transfers | 372/497 (74.8%) versus 328/495 (66.3%); absolute 8.6 points (95% CI 2.9-14.2); RR 1.13 (1.04-1.22); margin -10 points | Public multicenter hard-event single noninferiority trial |
Receipt — 1 References
All 1 cited sources were verified for existence at the original page (as of 2026-08-18).
Reviewed and approved: Chamgap Editorial Team · Approval date: 2026-08-18 · Corrections: none
Cite this verdict
[Chamgap] Single Blastocyst-Stage Transfer Benefits Cumulative Live Birth After up to Three Transfers in Good-Prognosis IVF Women Versus Cleavage-Stage Transfer — Evidence Grade B·72. 1 cited sources checked. Source: https://chamgap.com/en/verdicts/womens/single-blastocyst-versus-cleavage-stage-transfer-cumulative-live-birth-good-prognosis-ivf/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
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