Fermented porcine placenta extract,
does it really help with Improvement of fatigue?
research showsAn eight-week RCT randomized 84 adults and analyzed 67 per protocol, finding improved FSS and IL-1 beta with the HORUS fermented powder. Cortisol and lactate findings came from age or BMI subgroups. LG Household & Health Care sponsored the trial and company researchers were coauthors; this was one study of a specific fermented powder without independent replication, resulting in C.
ads claimAdvertising may present relief of daily fatigue, restoration of stamina, post-exercise recovery, and general vitality, while the direct evidence is an eight-week trial of one specific ingredient in otherwise healthy adults who reported fatigue.
Useful facts when choosing a product
- The study dose was 320 mg/day of fermented porcine placenta.
- The test material was a specific HORUS fermented powder providing a total of 200 micrograms/day of Gly-Leu and Leu-Gly.
- Efficacy was analyzed per protocol in 67 compliant participants rather than all 84 randomized participants.
- Ordinary porcine placenta powder, hydrolysates, and other fermented products are not the same test material.
What the research actually shows
Yoon 2020 randomized 84 adults aged 30 to 60 years with a Fatigue Severity Scale score of at least 27 to 320 mg/day of fermented porcine placenta or placebo for eight weeks. In the 67-person efficacy analysis, between-group changes in FSS and IL-1 beta mRNA were significant; cortisol improved among participants younger than 45 years, while lactate and myoglobin improved in the subgroup with BMI of at least 23. LG Household & Health Care sponsored the trial, and two company researchers were coauthors. No independent human replication with the same fermented ingredient was identified.
Why this is classified as C (50)
The direct patient-reported FSS improvement and IL-1 beta signal are recognized. Randomization of 84 with a 67-person per-protocol analysis, subgroup-only cortisol and lactate findings, LG Household & Health Care sponsorship and company coauthors, and one HORUS-specific trial without independent replication result in C with 50 points.
Counterpoint. An eight-week daily-fatigue signal remains for the standardized fermented ingredient, but it is not extrapolated to other placenta products or long-term clinical outcomes.
Rejudgment record. Reassessment (cross-check reflected) — An eight-week RCT randomized 84 and analyzed 67 per protocol, with positive FSS and IL-1 beta but subgroup-only cortisol and lactate, LG Household & Health Care sponsorship and company coauthors, one HORUS-specific fermented powder, and no independent replication
Cross-check — Codex and Claude
Evidence Table
| Study | Design | Sample | Funding | Endpoint | Result | Weight |
|---|---|---|---|---|---|---|
| Yoon DH et al. 2020 | Eight-week randomized double-blind placebo-controlled parallel trial | 31 | Sponsored by LG Household & Health Care with company researchers as coauthors | FSS and CIS questionnaires, post-treadmill lactate, myoglobin, cortisol, and inflammatory cytokines | FSS and IL-1 beta mRNA improved versus placebo; cortisol, lactate, and myoglobin were positive in age or BMI subgroups. | Key, single manufacturer-sponsored trial |
| Kang P et al. 2026 | Review of the regulatory system and individually recognized ingredients | Korean government research support | Classification of individually recognized fatigue-recovery ingredients | Listed fermented pig placenta extract as a Korean individually recognized fatigue-recovery ingredient. | Supportive for product status | |
| Kim HY et al. 2016 | Preclinical treadmill and forced-swim study in mice | Included researchers from LG Household & Health Care | Exercise duration, lactate, cytokines, and oxidative stress | Reported anti-fatigue signals for fermented porcine placenta and selected amino acids. | Preclinical, manufacturer-linked |
Receipt — 3 References
All 3 cited sources were verified for existence at the original page (as of 2026-07-11).
Reviewed and approved: Chamgap Editorial Team · Approval date: 2026-07-11 · Corrections: none
Cite this verdict
[Chamgap] Fermented porcine placenta extract x improvement of fatigue — Evidence Grade C·50. 3 cited sources checked. Source: https://health-receipt.pages.dev/en/verdicts/energy/fermented-porcine-placenta-fatigue/ · CC BY 4.0CC BY 4.0 — free to use with attribution; do not distort grades, numbers, or verdict meaning.
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